Вазопрессин

Мавод аз Википедиа — донишномаи озод
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Вазопрессин
Вуҷуд дорад дар таксони Homo sapiens[d][1]
Encoded by Вазопрессин[d][1]
Функсияи молекулярӣ protein kinase activity[d][2], hormone activity[d][3], cysteine-type endopeptidase inhibitor activity involved in apoptotic process[d][2], neurohypophyseal hormone activity[d][3], receptor binding[d][4][5], V1A vasopressin receptor binding[d][2][3], V1B vasopressin receptor binding[d][3], neuropeptide hormone activity[d][5][3][2], neuropeptide hormone activity[d][5][3][…] ва V1A vasopressin receptor binding[d][2][3][6]
Cell component extracellular region[d][3][3][3], cytosol[d][3], clathrin-coated vesicle membrane[d][3], extracellular[d][3], secretory granule[d][3], Дендрит[3], extracellular[d][3][6] ва secretory granule[d][3][6]
Biological process negative regulation of cysteine-type endopeptidase activity involved in apoptotic process[d][2], vasoconstriction[d][3], negative regulation of release of cytochrome c from mitochondria[d][2], ERK1 and ERK2 cascade[d][2], water transport[d][5], cell-cell signaling[d][5], negative regulation of apoptotic process[d][2], protein kinase C signaling[d][2], generation of precursor metabolites and energy[d][5], positive regulation of peptidyl-serine phosphorylation[d][2], positive regulation of gene expression[d][7], renal water homeostasis[d][3], signal transduction[d][4][2], апоптоз[d][3], membrane organization[d][3], regulation of receptor activity[d][3], G-protein coupled receptor signaling pathway[d][3], maternal aggressive behavior[d][3], positive regulation of systemic arterial blood pressure[d][3], positive regulation of cytosolic calcium ion concentration[d][3], negative regulation of female receptivity[d][3], personal grooming[d][3], locomotory behavior[d][3], positive regulation of cell proliferation[d][3], positive regulation of glutamate secretion[d][3], response to organic cyclic compound[d][3], positive regulation of cell growth[d][3], positive regulation of prostaglandin biosynthetic process[d][3], positive regulation of cellular pH reduction[d][3], response to testosterone[d][3], response to nicotine[d][3], social organism behavior[d][3], regulation of renal sodium excretion[d][3], hyperosmotic salinity response[d][3], maternal behavior[d][3], erection[d][3], response to ethanol[d][3], positive regulation of vasoconstriction[d][3], multicellular organismal water homeostasis[d][3] ва negative regulation of transmission of nerve impulse[d][3]
Gene Atlas Image

Вазопрессин (аз лот. vas — раг ва pressus — фишор) — ҳормони пептидӣ, ки дар ҳуҷайраҳои гипоталамус ҳосил мешавад.

Вазопрессин ба воситаи нахҳои бандчаи гипоталамусу ҳипофиз ба ҳуҷайраҳои ҳиссаи қафои ҳипофиз интиқол меёбад. Вазопрессин обро дар андомгон (организм) нигоҳ дошта, рагҳои хунро меангезад, ба маҷрои хун гузашта, барои дар савияи зарурии физиологӣ нигоҳ доштани мубодилаи обу намак кумак мерасонад. Ҳангоми бисёр рост истодан, беҳад гарм будани ҳаво, шӯру ғавғо, дард, зиқӣ, кори вазнини ҷисмонӣ, хунравӣ ва талафи об миқдори Вазопрессин дар хун меафзояд. Дар натиҷаи дароз кашидан, сард будани ҳаво, бисёр ошомидани об, истеъмоли машруботи спиртдор раванди ҳосил шудану ба хун гузаштани Вазопрессин коҳиш меёбад. Ихтилоли ҳосилшавии Вазопресин боиси сар задани диабети беқанд мешавад. Дар хуни одамони солим фақат бақияи Вазопрессин (дар 1 мл хун тақр. 4 микровоҳид), дар миқдори умумии пешоби шаборӯзӣ 40-60 микровоҳиди Вазопрессин мавҷуд аст.

Эзоҳ[вироиш]

  1. 1.0 1.1 UniProt
  2. 2.00 2.01 2.02 2.03 2.04 2.05 2.06 2.07 2.08 2.09 2.10 2.11 2.12 Chen J., Volpi S., Aguilera G. Anti-apoptotic actions of vasopressin in H32 neurons involve MAP kinase transactivation and Bad phosphorylation // Exp. Neurol.Elsevier, 2008. — Vol. 211, Iss. 2. — P. 529–38. — ISSN 0014-4886; 1090-2430; 1055-8330; 1522-9661doi:10.1016/J.EXPNEUROL.2008.02.023PMID:18402937
  3. 3.00 3.01 3.02 3.03 3.04 3.05 3.06 3.07 3.08 3.09 3.10 3.11 3.12 3.13 3.14 3.15 3.16 3.17 3.18 3.19 3.20 3.21 3.22 3.23 3.24 3.25 3.26 3.27 3.28 3.29 3.30 3.31 3.32 3.33 3.34 3.35 3.36 3.37 3.38 3.39 3.40 3.41 3.42 3.43 3.44 3.45 http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01185
  4. 4.0 4.1 G Innamorati, H Sadeghi, M Birnbaumer A fully active nonglycosylated V2 vasopressin receptor // Mol. Pharmacol.American Society for Pharmacology and Experimental Therapeutics, 1996. — Vol. 50, Iss. 3. — P. 467–73. — ISSN 0026-895X; 1521-0111PMID:8794883
  5. 5.0 5.1 5.2 5.3 5.4 5.5 U Bahnsen, P Oosting, Swaab D. F. et al. A missense mutation in the vasopressin-neurophysin precursor gene cosegregates with human autosomal dominant neurohypophyseal diabetes insipidus // EMBO J.Nature Publishing Group, 1992. — Vol. 11, Iss. 1. — P. 19–23. — ISSN 0261-4189; 1460-2075doi:10.1002/(ISSN)1460-2075PMID:1740104
  6. 6.0 6.1 6.2 Livstone M. S., Thomas P. D. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium // Brief. Bioinform.OUP, 2011. — Vol. 12, Iss. 5. — P. 449–462. — ISSN 1467-5463; 1477-4054doi:10.1093/BIB/BBR042PMID:21873635
  7. Belkacemi L., Beall M. H., Magee T. R. et al. AQP1 gene expression is upregulated by arginine vasopressin and cyclic AMP agonists in trophoblast cells // Life Sci.Elsevier, 2008. — Vol. 82, Iss. 25-26. — P. 1272–80. — ISSN 0024-3205; 1879-0631doi:10.1016/J.LFS.2008.04.014PMID:18538351

Адабиёт[вироиш]

  • Теппермен Дж. Физиология обмена веществ и эндокринной системы. М., 1989;
  • Шмидт Р., Тевса С. Физиология человека. М., 1996.

Сарчашма[вироиш]